Abstract

MEDICINAL TRENDS OF LACTULOSE AS PREBIOTICS

Isha Choudhary and Deepa Srivastava*

ABSTRACT

Lactulose, non-absorbable disaccharides compose of galactose and fructose, has gained significant attention in the field of medication due to its diverse pharmacological properties and numerous clinical applications. Lactulose is being explored for its potential benefits in management of constipation and hepatic, has garnered significant attention as a prebiotic due to its beneficial effects on gut health. This non-digestible food ingredient reaches the colon intact, where it serves as a substrate for beneficial gut bacteria, promoting their growth and activity. Bifidobacteria and lactobacilli, the primary beneficiaries of lactulose fermentation, produce short-chain fatty acids (SCFAs) during this process. SCFAs play a crucial role in maintaining a balanced gut microbiota, fostering better digestion, reducing inflammation, and supporting immune function. Additionally, lactulose's ability to draw water into the colon makes it a valuable agent in the management of constipation.

Keywords: Prebiotics, lactulose, HE (Hepatic encephalopathy), T2D (type2 diabetes), short chain fatty acid, microbiota.