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Abstract

MICROSPHERES: FORMULATION & EVALUATION

*Piyush Gupta, Shweta Parasher

Department of Pharmaceutics, Regional College of Pharmacy, Jaipur, (Raj.) 302022, India.

ABSTRACT

The term Microsphere is defined as a spherical particle with size varying from 50 nm to 2 µm, containing a core substance. Microspheres are, in strict sense, spherical empty particles. However, the terms microspheres and microencapsulation are used synonymously. In addition, some related terms are “beads” are used alternatively. Spheres and spherical particles are also used for a large size and rigid morphology. The microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers, which are biodegradable in nature, and ideally having a particle size less than 200 micrometer. Novel drug delivery systems are developed to address the challenges of drug development such as bioavailability, permeability & poor solubility. These demand changes in the conventional use of excipients, the growth of the biotechnology industry, including stem cell therapy. Vaccines & genetic products, also necessitates different drug delivery requirements, thereby demonstrating the acceptance of these excipients by the US food & drug administration or other agencies in the major markets. For materials in which Toxicity is a possible concern, formulators can give information about the excipients regulatory acceptance & allowable amount by consulting with excipients manufactures & toxicology experts.

Keywords: Microsphere, Nano particles, Drug carrier, PMMA(Polymethylmethacrylate).


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