Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF ANTIEMETIC DRUG METOCLOPRAMIDE

A. Geetha lakshmi*, Ravi Patel, Divya S Kumar

ABSTRACT

Metoclopramide hydrochloride(MH) is chemically 4-amino-5-chloro- N[2-(dimethylamino)-ethyl]-2-methoxybenzamide monohydrochloride monohydrate. It is a potent dopamine receptor antagonist. It is a potent antiemetic and is effective in the treatment of nausea and vomiting associated with cancer chemotherapy, pregnancy, migraine etc. It is also used for the treatment of diabetic gastric stasis and gastrooesophageal reflux disease. The fast dissolving tablet was prepared by using different superdisintegrant with different ratio. FT-IR study revealed no interaction between the drug and excipients. Tablets were characterized for hardness, friability, weight variation, wetting time, disintegration time, drug content, dissolution and dispersion time. Among the nine formulations, F6 was selected as the best formulation as its wetting time was 39 seconds, disintegration time was 12 seconds, dispersion time was 49 seconds and %CDR after 6 minutes was 99.46%. F6 was found to be stable at 40 °C ± 2 °C and 75 ± 5 % RH which was confirmed by FT-IR study.

Keywords: Metoclopramide hydrochloride, Fast dissolving tablet, Superdisintegrants.