Abstract

A REVIEW ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ESCITALOPRAM OXALATE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM

Mahesh Dilip Gade*, Dr. Narendra M. Gowekar and Vanita N. Gade

ABSTRACT

Analytical methods development and validation play important roles in the discovery, development and Manufacture of pharmaceuticals. Method development is the process of proving that an analytical method is acceptable for use to measure the concentration of an API in a specific compounded dosage form which allow simplified procedures to be employed to verify that an analysis procedure, accurately and consistently will deliver a reliable measurement of an active ingredient in a compounded preparation. Liquid chromatography with UV detection has been found to be most studied for estimation of Escitalopram Oxalate in bulk as well as pharmaceutical dosage forms, while hyphenated LCMS, LC- MS/MS methods reported for determination of Escitalopram Oxalate and its metabolite in plasma and other biological fluids. Few chromatography approaches like HPTLC and Stability indicating HPLC, UPLC and HPTLC are also reported. Few simple UV -Spectrophotometric methods may be used for routine analysis of Escitalopram Oxalate alone and in combination with other drugs. These compiled data may of use for research for further studies in analysis of Escitalopram Oxalate.

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