Abstract

PHARMACOSOMES: ADVANTAGE OVER THE TRADITIONAL VESICULAR DELIVERY SYSTEM IN BRAIN TARGETING.

Amruta Pol*, Rachana Sarawade

ABSTRACT

Various drug delivery systems are emerging for CNS-related disorders. The main aim of the formulations is to develop a system that will cross the blood-brain barrier (BBB) and increase the bioavailability of drugs. Pharmacosomes are a potential approach in a vesicular drug system that exhibits several advantages over conventional vesicular drug delivery systems. Pharmacosomes are phospholipid complexes with the potential to improve the bioavailability of poorly water-soluble as well as poorly lipophilic drugs, minimize GI toxicity, and improve the drug's short half-life. Parkinson's disease and Alzheimer’s disease are major CNS disorders that need to be explored for better drug delivery systems. Pharmacosomes are suitable candidates for hydrophilic and lipophilic drugs. This article reviews the potential of pharmacosomes, showing improved oral bioavailability and controlled drug delivery of drugs.

Keywords: Pharmacosomes, CNS, Phosphatidylcholine, Drug-acid complex.