Abstract

ALOE VERA AS A POTENTIAL HERBAL FOR DIABETES TYPE 2 DRUG DEVELOPMENT

*Ly Le

ABSTRACT

Diabetes is a symptom which is too much glucose, a type of sugar, in the blood. Scientists use another name: hyperglycemia. There are two main types of diabetes – type 1 and type 2. Type 2 is the most common form of diabetes, it’s when your bodies do make insulin but either pancreas does not make enough insulin or the bodies cannot use the insulin well enough, or we call insulin resistance. In aloe vera, there exists a quite huge number of biocompounds which have the ability to treat the disease. Applying the GaussView, AutoDock Vina and LigandScout softwares to perform and discover the most potential ones, finally they are Saponin B, Aloe Emodin, Aloin A and B, Gibberellins, IAA, IBA, NAA, Beta-sitosterol, Salicylic acid. Based on the 5 rules of Lipinski, Saponin B, Aloe Emodin, Aloin A and B, Gibberellinsare the suitable compounds for drug design and development.

Keywords: aloe vera, diabetes type 2.