Abstract

RECENT ADVANCES IN MUCOADHESIVE OCULAR DRUG DELIVERY SYSTEM: A REVIEW

Seraj Alam Siddique*, Bhagyashree Prabhat, Mohd Kalim and Ankur Yadav

ABSTRACT

The current article has been mainly highlighted on the mucoadhesive drug delivery system that can be designed to shows prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome. For the application of dosage forms to mucosal surfaces which having many benefits to drug molecules not only for the oral route, which undergo acid degradation or extensive first-pass metabolism in the stomach. The main challenges in ocular drug delivery occurs due to unique anatomy and physiology of eye in comparison to other organs of the body. The conventional formulations like solution, suspensions and ointments having many demerits such as rapid precorneal elimination, high variability, drainage by gravity and absence of controlled release. Novel pharmaceutical ophthalmic formulations like in-situ gel, nanoparticle, liposome, nanosuspension, microemulsion, iontophoresis and ocular inserts have been developed in last three decades which provides increase in the solubility and bioavailability of the drug as a sustained and controlled manner to overcome these types of problems. There is a need to develop ocular drug delivery systems which gives sustained and controlled release for the treatment of chronic diseases and increase patient’s and doctor’s convenience to reduce the dosing frequency and invasive treatment. In this article, improvement of ocular drug delivery systems under clinical trials and in late experimental stage is reviewed.

Keywords: Mucoadhesive, First-Pass Metabolism Bioavailability, Iontophoresis, Ocular Insert, In-situ gel, Nanoparticle, Liposome, Nanosuspension, Microemulsion Invasive Treatment.