Abstract

EVALUATION OF NEPHRO PROTECTIVE ACTIVITY ON BARK OF SOYMIDA FEBRIFUGA

Dr. G. Veda Priya* and Dr. K. Swathi Priya

ABSTRACT

The present study was carried out to evaluate the nephroprotective activity of traditional medicinal plant Soymida febrifuga belonging to the family Meliaceae. The bark part was selected for the activity and extracts were prepared using maceration procedure using different solvents successively. Different extracts of selected plants tested for preliminary phytochemical screening showed the presence of phytosterols, triterpenes, glycosides, alkaloids, flavonoids and carbohydrates. Acute toxicity studies were performed using hydroalcoholic extract as per guidelines in which selected plant extract showed neither visible sign of toxicity nor mortality. Nephroprotective activity was carried out using hydroalcoholic extract at 250 and 500 mg by estimating the biochemical parameters such as blood urea, serum creatinine, bilurubin and total protein. From the observed values the percentage protection of hydro alcoholic extract were plotted to compare biochemical parameters of all treatments with negative control values. The results were expressed Mean ±S.E.M, n=6 and significant values were expressed as P<0.05. The results of the present study provides the evidence on nephroprotective activity of selected medicinal plants and there is a scope to further studies on isolation of compounds from these species.

Keywords: Soymida febrifuga, bark, phytochemical screening, nephroprotective activity.