Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE MUCOADHESIVE TABLETS FOR TREATMENT OF HYPERLIPIDEMIA

Sapna Verma*, Arindam Chatterjee, Anil Jangid and Rakesh Gupta

ABSTRACT

The objective of present research work is to formulation and evaluation of gastroretentive mucoadhesive tablets of treatment of hyperlipidemia. Total nine formulations were prepared for Simvastatin gastroretentive mucoadhesive tablets by using different natural polymers. The bulk density and the tapped density for all the formulations varied from 0.236 to 0.263gm/cm3 and 0.336 to 0.374gm/cm3 respectively. The result of Hausner‟s ratio of all formulations ranges from 1.333 to 1.544 which indicates that the flow ability of all the formulation. The results of the Compressibility index of all the formulations ranges from 25.000% to 35.870%. The thickness depends on the size of the punches (8 mm) and the weight of one tablet (150mg). The value of thickness ranges between 2.10±0.02 to 2.15±0.01mm. Friability determines the strength of the tablets. The friability for all the formulations was below 1% indicating that the friability was within the prescribed limits. The friability value ranges from 0.623±0.008 to 0.862±0.014. The mean hardness values were measured for all the formulation using Monsanto hardness tester. The hardness value ranges from 5.1±0.2 to 5.3±0.3kg/cm2. Twenty tablets were randomly selected from each formulation and evaluated. The values of tablets average weight ranging from 145±2 to 153±5mg. All the tablets passed weight variation test as the % weight variation was within the USP Pharmacopoeia‟s limits of ±7.5% of the weight. The % drug content of all the formulated tablets were found within the limit. % drug content value of Simvastatin was within 98.78±0.15% to 99.45±0.23%.The results within the range indicate uniform of mixing. In vitro drug release studies were performed by using USP XXIII dissolution test apparatus II at 50rpm using 900 mL of 1.2 pH buffer maintained at 37±0.5ºC as the dissolution medium. When the regression coefficient values of were compared, it was observed that „r‟ values of First order was maximum i.e. 0.960 hence indicating drug release from formulations was found to follow First order release kinetics.

Keywords: Swelling index, mucilage, percentage yield, mucoadhesive, therapeutic.