Abstract

A REVIEW OF RECENT TRENDS IN NON-INVASIVE INSULIN THERAPY FOR DIABETES MELLITUS

S. Bala Murali Mohan*, Deepthi.B , Gourineny Bhanusree

ABSTRACT

Diabetes mellitus is generally a chronic condition associated with abnormally high levels of sugar (glucose) in the blood. Insulin is used for treating diabetes particularly of type I DM and selectively of type II DM patients. Presently available methods of administration of insulin are insulin syringes, insulin infusion pumps, jet injectors, insulin pens and the traditionally used method of administration i.e.; subcutaneous route are of invasive in nature. In order to reduce the pain of the patients, several approaches of non-invasive delivery of insulin are being developed. The newer non-invasive methods available are inhaled insulin, oral insulin, buccal insulin and transdermal delivery of insulin. This paper reviews the recent developments in noninvasive delivery of insulin with their formulation aspects and their advantages over invasive delivery of insulin. (DM- DIABETES MELLITUS).

Keywords: Diabetes Mellitus, insulin, inhaled insulin, oral insulin, buccal route and transdermal route.