Abstract

A REVIEW ON: ANALYTICAL METHOD FOR DETERMINATION OF EFONIDIPINE HYDROCHLORIDE ETHANOLATE AND CHLORTHALIDONE

Sushma D. Gohil* and M. Meera Devi

ABSTRACT

Efonidipine Hydrochloride Ethanolate is the L- type and T-type calcium channel blocker of Dihydropyridine class of drug. It is chemically 2-(N-benzyl anilino) ethyl 5-(5, 5-dimethyl-2-oxo-1,3,2λ5- dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1, 4dihydropyridine- 3 carboxylate; ethanol; hydrochloride. It has negative chronotropic and vasodilator effect. Chlorthalidone is a Thiazide¬ - diuretic class of drug. It is chemically is 2-chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl) benzene sulfonamide. Which lowers blood pressure by removing extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow. Combination of both drugs used in the treatment of mild to moderate hypertension in adult patient whose blood pressure is not adequately controlled by monotherapy. Two simple, precise and economical UV spectrophotometric methods have been developed for the simultaneous estimation of Efonidipine Hydrochloride Ethanolate and Chlorthalidone in their synthetic mixture. This review focuses on the recent developments in analytical techniques for estimation of Efonidipine Hydrochloride Ethanolate and Chlorthalidone.

Keywords: Efonidipine Hydrochloride Ethanolate, Chlorthalidone, Analytical Techniques.