Abstract

SYNTHESIS OF SCHIFFS BASE DERIVATIVE AND EVALUATION OF ITS ANTIMICROBIAL ACTIVITY

M. Sangeetha M. Pharm (Ph.D)*, A. Bhavana Reddy, B. Keerthi Reddy and C. Pranathi Sena Reddy

ABSTRACT

Researchers’ interest in Schiff bases prepared from ortho-hydroxyl aromatic aldehydes is due to their ability to act as bidentate ligands for transitional metal ions. Later, in studies, it has been observed that azomethines from salicylaldehyde’s gave the best quantitative structure-antitumor activity relationship which has been studied for a series of Schiff bases derived from a variety of substituted aromatic amines and aldehydes. Schiff bases are active against many organisms such as Erysiphe graminis, Bacillus polymxa, Staphylococcus aureus, Candida albicans, Escherichia coli, Trychophytongypseum, Plasmoporaviticola, and Mycobacteria. They have shown excellent stability, and selectivity for specific metal ions such as Pb (II), Co (II), Al (III), Ag (II), Gd (III), Cu (II), Ni (II), Y(III), Zn (II), and Hg (II), so that large number of different Schiff base ligands have been used in potentiometric sensors as cation carriers. The principal interaction between the Metal surface and inhibitor is Chemisorption. The inhibitor molecule should have centers that can form bonds with the metal surface by electron transfer. In such cases, the inhibitor acts as a Lewis base and the metal acts as an electrophile.

Keywords: Schiff’s base, structure activity relationship, antiviral activity, basicity.