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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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Abstract

FORMULATION AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF DOLUTEGRAVIR

Dr. Shaik Shabbeer*, M. Roopa Rani, A. Vaishnavi, U. Sandhya Rani, SK. Subanbee, B. Suchithra, MD. Firdous Khan, Dr. CH. V. Suresh and Dr. K. N. V. Rao

ABSTRACT

The present investigation was to develop Dolutegravir controlled release 250 mg matrix tablets. Dolutegravir is a second generation HIV integrase strand transfer inhibitor (INSTI). Six formulations of Dolutegravir 250 mg were formulated by direct comparison using different polymers like Hupu gum, Gum Karaya & HPMC were used as rate controlling step. The formulation F2 was selected as an optimised formulation because it gives best results in terms in vitro drug release in controlled manner.

Keywords: Dolutegravir, Controlled release, Matrix tablets, Hupu gum, Gum karaya & HPMC.

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