Abstract

SUSTAINED RELEASE GLIBENCLAMIDE MICROSPHERES BY DOUBLE EMULSIFICATION SOLVENT DIFFUSION METHOD

Swathi Kovvuri and Jeevana Jyothi B.*

ABSTRACT

Sustained release formulations are more patient-friendly and lend themselves for low dosing frequency and less side effects. Double emulsification solvent diffusion method is the method to produce microspheres to exhibit sustained release. Hence in the present work, glibenclamide is prepared as microspheres by double emulsification solvent diffusion method using ethyl cellulose as a polymer in the form of sustained release dosage forms, expecting patient-friendly administration with a lower dosing frequency. Microspheres containing 2.5 mg of glibenclamide were prepared by the water-in-oil-in-oil (w/o/o) double emulsion solvent diffusion method. The prepared microspheres were evaluated by particle size, percentage yield, entrapment efficiency, in-vitro drug release studies, XRD, SEM, FTIR and DSC. Glibenclamide microspheres were obtained as discrete, free-flowing microspheres with a size range of 456 m to 991 m and a percentage (61.25 to 90.93%) with reasonable entrapment efficiency values of 76.7% to 93.22%. FTIR and DSC analysis revealed compatibility between glibenclamide and ethyl cellulose. F10 formulation containing ethyl cellulose and liquid paraffin shows a high percentage of drug release. Data obtained from the drug release are fitted to various kinetic models, and higher correlations are obtained in the Higuchi and zero orders. The drug release was found to be due to diffusion and erosion.

Keywords: Glibenclamide, Double emulsion solvent diffusion, Microspheres, Sustained release.