Abstract

EVALUATION OF RADICAL SCAVENGING EFFECT OF MORINDA CITRFOLIA FRUIT

Vennila Srinivasahan and Brindha Durairaj*

ABSTRACT

Objectives: The present investigation was designed to evaluate the radical scavenging effect of hydroethanolic extract and aqueous extract of Morinda citrifolia fruit. Methods: The study was performed to investigate for the activity of scavenging free radicals such as 1,1 – diphenyl 2-picryl hydrazyl radical (DPPH), Superoxide anion, hydroxyl and nitric oxide radical scavenging effect an aqueous and hydroethanolic extract of the fruit Morinda citrifolia. The scavenging activity of the fruit extract was tested at different concentrations (100, 200. 300, 400, and 500 μg/ml). Results: Both hydroethanolic and aqueous extract showed concentration dependant free radical scavenging activity. Hydroethanolic extract exhibited maximum scavenging activity against DPPH (69.73%), hydroxyl radical (64.45%), superoxide radical (58.79%) and nitric oxide radical (58.72%) when compared with aqueous extract. Conclusion: These results clearly indicate that hydroethanolic extract of Morinda citrfolia fruit is effective in preventing the progress against various free radical mediated diseases.

Keywords: Morinda citrifolia, DPPH, Radical scavenging, IC50.