Abstract

DELPHINIDIN AS AN ANTIOXIDANT AGENT OF NITROGENOUS BASES OF NUCLEIC ACIDS USING QUANTUM CHEMISTRY

Michelle Isasmendi-Cortés, Osvaldo Sánchez-Hernández, Héctor Miguel Juárez-Sánchez, Marbella Martínez-Rodríguez, Aidee Carolina Domínguez-Luna, Fanny Montes-Damián and *Manuel González-Pérez

ABSTRACT

Delphinidin (DPN) is a natural chemical compound of the anthocyanins (ACNs) type or natural pigment. DPN is a bioactive compound from the calyces of Hibiscus sabdariffa L. (Malvaceae) (Roselle), and these have anti-inflammatory properties, including antioxidant, antiangiogenic, and anticancer properties. The objective was to analyze the interactions of DPM vs. nitrogenous bases (NBs) of nucleic acids. Quantum chemistry was used—Hyperchem software. SE-PM3 method and Polak Reviere. The calculus was made by Electron transfer coefficient (ETC) theory. The DPN forms micelles due to a quantum superposition of its HOMO and LUMO electron clouds. DPN is a long-acting substance in the human body. DPN does not attack NBsin their allowed interactions (hydrogen bonding) because their interaction has a higher ETC value.

Keywords: Delphinidin, Antioxidant, DNA, RNA, Quantum chemistry.