Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF 2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1-[1-(4- HYDROXY-6-METHYL- PYRAN-2-ONE-3- YL)ETHYLIDENE]HYDRAZINE SCHIFF’S BASE TRANSITION METAL COMPLEXES: ANTIBACTERIAL AND DNA PHOTOCLEAVAGE STUDY

A. K. Gupta*, S. Saini, R. Pal, R. Kumar, V. Beniwal

ABSTRACT

The synthesis of a series of some new tridentate Schiff’s base complexes of Cu(II), Ni(II), Co(II), Mn(II), Zn(II) (M:L=1:2) with a tridentate Schiff’s base has been achieved by the reaction of 2- hydrazino-4,6-dimethyl pyrimidine with dehydroacetic acid (DHA) in ethanol under reflux. All the compounds were characterized on the basis of elemental analysis, UV-Visible, 1H and 13C-NMR, FTIR spectroscopy and mass spectrometry. The FTIR spectral data suggest that azomethine N and enolic O atoms are involved in coordination with metal ion, and the ligand behaves as a N,N,O-tridentate donor atoms. The mass spectrum of the complexes reveals the formation of metal ligand bonding in 1:2 (metal: ligand) stoichiometric ratios. All the synthesized compounds were screened for their antibacterial activity against gram (+) and gram (-) bacteria using Oxacillin as a standard drug. Synthesized compound were also screened for their DNA photocleavage potential using plasmid DNA. It has been found that metal complexes show enhanced activity as compared to ligand and some modification in ligand structure may lead to better antibacterial and DNA photocleaving agents in future.

Keywords: Dehydroacetic acid, 2-Hydrazino-4,6-dimethylpyrimidine, Schiff’s base, metal complexes, DNA photo cleavage and antibacterial activity.