Abstract

FORMULATION AND EVALUTION OF LIPOSOMAL TRANSDERMAL PATCH OF CURCUMIN

Anju Vaishnav*, Dr. Nishith Patel and Dr. Chaitanya Bhatt

ABSTRACT

Curcumin liposomal transdermal patches were successfully prepared by solvent casting method using different synthetic polymers. Drug excipient compatibility studies concluded that the drug and excipient are compatible with each other. The prepared patches were evaluated for physico-chemical parameters to justify their suitability for transdermal use. Formulations containing Eudragit NE 40D with plasticizer propylene glycol gives best drug release in 12 hours. More than 90% drug release found after 12 hours in formulation F5. Hence F5 formulation is considered as optimized batch and further optimization using DoE software was done. Factorial design was applied for formulation optimization. Based on factorial design and factorial batches results, it found that the all the results are found satisfactory and gives sustained drug release up to 12 hours and have good mechanical properties. Further Validation of design was done and found satisfactory. Model found significant for all three responses. Finally, optimized batch O1 was selected from the design and completed evaluation of O1 batch was done. Batch O1 found stable for 1 month during stability study. Hence, O1 batch was considered as optimized batch.

Keywords: Curcumin liposomal transdermal patches, Eudragit NE 40D.