Abstract

FORMULATION AND EVALUATION OF FLOATING HBS CAPSULES OF CEFADROXIL

*G. Venkata Sowmyasree, Y. Nagarjuna Reddy and M. Akhilesh

ABSTRACT

The objective of this present investigation is to develop gastro retentive Controlled release HBS Capsules of Cefadroxil by the Simple blending method. The floating HBS Capsules of Cefadroxil were prepared by using lactose, HPMC K4M, PVP K 30, Magnesium stearate. Which may increase the mean residence time in the gastrointestinal tract, and may be able to provide maximum drug at the site of absorption to improve oral bioavailability. All these formulated HBS capsules were floated well over 12 h with no floating lag time. They also showed drug release over 6 h. Prepared HBS Capsules were evaluated for drug content, weight variation, content uniformity, buoyancy test, disintegration studies, drug release studies. All of the formulations (F1 to F4) were floated well over 12 h with no floating lag time. In vitro dissolution studies were performed for twelve hours into 900 ml 0.1N HCl (pH 1.2) using USP Apparatus II (paddle type) maintained at a temperature of 37ºC and stirred at a speed of 50 rpm and λmax of 263nm. The dissolution study revealed that, after twelve hours the percent of drug release for four formulations were 79.41±0.85 (F1), 81.08±0.97 (F2), 83.84±0.85 (F3), 85.19±0.95 (F4), and all of the formulations followed zero order, First order, Higuchi model, and Peppas model.

Keywords: Floating-HBS Capsules, Cefadroxil, weight variation, content uniformity, disintegration studies etc.