Abstract

AN OVERALL REVIEW OF ANALYTICAL AND BIOANALYTICAL METHODS DEVELOPED FOR THE ESTIMATION OF ATENOLOL

Logeshwaraan Murugan, Dr. J.S.K. Nagarajan*, Ramakrishnan Raja, Shambhavi Shahi, Rudranil Karmakar and Debarya Baneerjee

ABSTRACT

Atenolol is a synthetic isopropylaminopropanol derivative that acts as a beta-selective (cardioselective) beta-adrenergic receptor blocking drug with no membrane stabilising or intrinsic sympathomimetic (partial agonist) activity. It is a hydrophilic β1 cardioselective - adrenergic receptor-blocking drug that is commonly used to treat hypertension, arrhythmias, and angina pectoris. Several methods to identify Atenolol in pharmaceutical formulations and biological samples have been developed and validated. Additionally, further articles on the Analytical and Bio-Analytical method-based quantification of atenolol in pharmaceutical formulations and biological samples were published. This entire paper represents the many approaches and methodologies used for atenolol estimation in various instruments such as HPLC, LC-MS/MS, UV, UPLC, and HPTLC. As a result, publications published from 2012 to the present were collected and reviewed for atenolol analysis in pharmaceutical formulations and biological samples.

Keywords: Atenolol, Biological Samples, Pharmaceutical Formulations, HPLC, LC-MS/MS, UPLC-MS,UV.