Abstract

A REVIEW ON: VALIDATION OF DEVELOPED ANALYTICAL METHODS FOR THE DETERMINATION OF DEXTROMETHORPHAN HYDROBROMIDE AND BUPROPION HYDROCHLORIDE IN PHARMACEUTICAL DOSAGE FORMS

Dhara Vashi1, Vishnu Sutariya, Monika Kakadiya and Darji Parvinbanu*

ABSTRACT

Dextromethorphan Hydrobromide is a class of antitussive agent and Bupropion Hydrochloride is an antidepressant. Combination of both drugs are used to treat major depressive disorder. Dextromethorphan hydrobromide is an Uncompetitive NMDA receptor antagonist and sigma 1 receptor agonist, Bupropion hydrochloride is an aminoketone and CYP450 2D6 inhibitors. They are generally administered as a sustained release tablet. This review focuses on the recent developments in analytical techniques for estimation of Dextromethorphan hydrobromide and Bupropion hydrochloride, and only one method is reported for this combination. However Official compendia methods, UV, HPLC, UPLC, Stability indicating RP-HPLC and HPTLC methods have been reported for both drugs individual and along with other drugs. Methods indicating human plasma stability and impurity profile are also described for both drugs. This review also provides detailed information on separation condition for Dextromethorphan hydrobromide and Bupropion hydrochloride alone in presence of combination with other and in presence of its degradation products.

Keywords: Dextromethorphan Hydrobromide, Bupropion Hydrochloride, UV -Visible Spectrophotometry, RP-HPLC, UPLC, HPTLC, Stability indicating RP-HPLC Method.