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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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Abstract

PSIDIUM GUAJAVA LEAVES EXTRACT AND ANTIDIABETIC: CARDIOPROTECTIVE EFFECTS IN DIABETIC MALE WISTAR RAT

Uthman Ademola Yusuf*, Abigail Banda, Christine Banda, Sam Beza Phiri, Michelo Miyoba, Aminat Adejoke Yusuf, John Mulemena, Kingsley M Kamvuma and Olubukola Iyanuoluwa Ademola

ABSTRACT

For years herbs have been used in the management of ailments including diabetes. The purpose of this research was to investigate the cardioprotective effects of Psidium guajava leaves aqueous extract on streptozotocin induced diabetic Wistar rats. The 30 male Wistar rats were randomly selected into 5 groups; normal control, diabetic group, diabetic +guava leaves extract, diabetic +metformin and guava leaves extract only. The rats in diabetic, diabetic +guava leaves extract, diabetic +metformin groups were injected with a single dose of streptozotocin of 70mg/kg BW intraperitoneally. The aqueous guava leaves extract and the metformin were given via an oro-gastric cannula daily for 4weeks at a dose of 200mg/kg and 100 mg/kg body weight. At the end of the fourth week of treatment, the body weight and blood glucose levels in diabetic +guava leaves extract and diabetic +metformin groups was statistically significant when compared to diabetic group (P<0.05) while diabetic group was statistically significant when compared to control group (P<0.05). The relative weight of the heart in group B was significantly decreased when compared to other groups (P<0.05). The histological analysis of the control group and guava only group showed normal heart histoarchitecture. The diabetic group showed a high degree disorganization and degeneration of cardiomyocytes and collagen deposition. The diabetic +guava leaves extract and diabetic +metformin groups showed few degeneration cardiomyocytes and few collagen depositions. In conclusion, Psidium guagava leaves aqueous extract showed enhancement effects on the heart of the Wistar rate against the damage caused by diabetes.

Keywords: Eosin and Hematoxylin stain, Psidium guajava Leaves, Metformin, Wistar rats and streptozotocin.

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