Abstract

TRANSDERMAL PATCH OF ACECLOFENAC

Mohit Kumar*, Aman Singh Pathania, Hardeep Kaur, Dr. Rajesh Gupta and Dr. Nitan Bharti Gupta

ABSTRACT

This study has been undertaken to investigate the Transdermal drug delivery has made an important contribution to medical practice. It is a medicated patch that delivers a specific amount of medication through the skin into the blood stream. An advantage of a transdermal drug delivery route over other types of medication delivery is that the patch provides a controlled release of the medication into the patient, usually through either a porous membrane covering a reservoir of medication or through body heat melting thin layers of medication embedded in the adhesive. Aceclofenac the most commonly used medications for the treatment of pain and inflammatory reaction but various side effects can limit their use. Therefore, transdermal delivery of these drugs has advantages of avoiding hepatic first-pass effect, gastric irritation and delivering the drug for an extended period of time at a sustained level. The prepared patches possessed satisfactory physicochemical characteristics i.e. thickness, moisture content, drug content, moisture uptake, moisture loss, flatness, film thickness (mm), weight variation test (gm) and folding endurance number. This review article is about the transdermal patches of aceclofenac which includes advantages, ideal characters, formulation defect and evaluation.

Keywords: Aceclofenac, Menthol, Chloroform, Ethyl cellulose.