Abstract

A REVIEW ARTICLE ON THE GASTRO-RETENTIVE FLOATING MICROSPHERE OF PIOGLITAZONE

Nitin Kumar*, Mukesh Kumar, Deeksha Singh, Umesh Kumar Sharma and Prabhakar Vishvakarma

ABSTRACT

The key obstacle in the process of developing a system for the oral administration of a drug is not only to maintain the drug release but also to lengthen the presence of the dosage form within the gastrointestinal tract until the entire drug is released at the desired rate and in the desired amount of time. The goal of the floating microspheres is to increase the amount of time that gastric retention is achieved. Floating drug delivery systems have a smaller bulk thickness than gastric juice and are able to keep floating on gastric juice for an extended period of time without affecting the rate at which the stomach empties, hence boosting bioavailability. There are many different dose forms available for gastro retentive medications, such as tablets, capsules, pills, laminated films, floating microspheres, granules, and powders. The homogeneous distribution of these multiple-unit dosage forms in the stomach, which results in more repeatable drug absorption and lower risk of local discomfort, has brought a lot of attention to floating microspheres recently. The goal of this review is to compile contemporary research on the method of production, as well as the numerous aspects that affect the performance and characterisation of floating microspheres, and present that information in an organized fashion.

Keywords: Floating Microspheres, Approaches, Polymer, Mechanism, Methods.