Abstract

FEATURES AND FACTS OF MUCOADHESIVE BUCCAL TABLET: AN OVERVIEW

Salva Midhat Shaikh*, Diksha Kachare, S. B. Bothara

ABSTRACT

The phenomenon of interfacial molecular attractive forces between the surfaces of the biological substrate and the natural or synthetic polymers, which permits the polymer to cling to the biological surface for an extended length of time, is known as bioadhesion. For a very long time, products for a variety of biomedical uses, such as denture adhesives and surgical glue, have been made using bioadhesive polymeric systems. A cute pathway for systemic drug delivery within the mouth mucosa is provided by the buccal area of the oral mucosa. Drugs are delivered through the oral mucosa, which has a high first-pass metabolism and degrades in the gastrointestinal system. The buccal drug delivery method instantly delivers the medicine into the bloodstream, resulting in painless administration, rapid enzymatic activity, reduced hepatic metabolism, and high bioavailability. The disadvantages of the oral drug delivery route include substantial presystemic metabolism, which causes medicines to break down due to poor absorption in an acidic environment. This review paper provides a comprehensive overview of the oral mucosa, mucoadhesion, factors affecting mucoadhesion, Criteria for the selection of drug, Mucoadhesion polymer, and Example of patent available for buccal tablet, Evaluation method.

Keywords: Buccal mucosa, Bucoadhesion, Bioadhesive polymers, Dosage form.