Abstract

THE THERAPEUTIC EFFECT OF DRIED CLOVE ON IMMUNE SYSTEM IN EXPERIMENTAL RATS

Naeem M. Rabeh, Mahmoud F. Sayed* and Nafisa H. Al-Banna

ABSTRACT

Immunity has a vital role in defending the body against infectious diseases. Phytochemicals stimulate the immune system to defend against diseases. Cloves are one of the highest sources of phytochemicals that have many benefits for immunity, including antioxidants and Immunomodulatory, antitumor properties and helps in allergy, and respiratory. The aim of the study is to evaluate the therapeutic effect of dry clove supplementation on the immune system of rats with induced immune suppression. Thirty-five adult albino rats were divided into 5 groups, 7rats each. The 1st group (n=7) was fed on the basal diet (-ve control). The other 4 groups of the rat were injected with sheep red blood cells (SRBC) as a foreign antigen to induce immunosuppression, 3 groups of them were fed on basal diet and supplemented with, 2, 4, 6 % of clove bud powder for 8 weeks. The results showed a significant (P<0.05) enhancement of serum IgG, IgM, Albumin and Globulin as well as improving the liver enzymes as compared to the positive control group. Hematological parameters were significantly (P<0.05) increased for the groups given dried clove however, white blood cell was significantly (P<0.05) decreased. It was also observed a significant increase in the levels of glutathione peroxidase while malondialdehyde was significantly decreased as compared to the control positive group. It was concluded that clove supplementation stimulates shows the immune system of rats.

Keywords: Clove, Immune system, Phytochemicals, Hematological parameters, liver enzymes.