Abstract

IN-SITU GEL: A NOVEL APPROACH FOR CENTRAL NERVOUS SYSTEM DISORDERS

Shruti Gotmare*, Rashmi Khope, Nitin Padole, Nilakshi Dhoble, Pankaj Dhapke and Jagdish Baheti

ABSTRACT

The in-situ gel system has emerged as one of the best novel drug delivery systems; it helps for the sustained and controlled release of drugs by its special characteristic feature i.e., it converts solution into gel phase. It reaches the brain by passing through the blood-brain barrier and the desired mechanism of action is achieved for treating various CNS disorders. In addition, to improve bioavailability, this gel is also used to make the drug increase the residence time in the area of use, so that it can provide maximum effectiveness via enhancing percent permeation. It goes through different evaluation parameters like gel strength, gelling time, mucoadhesive strength, and percent drug release. The nasal route shows better systemic bioavailability due to its large surface area, porous endothelial membrane, high total blood flow, and avoidance of first-pass metabolism. The purpose of this study is to select the appropriate pH-sensitive polymer and its concentration, that will transform sol-to-gel at nasal pH, to provide direct release of the drug in the brain through olfactory nerves, and to prolong the drug retention time in the nasal cavity. In-situ is a Latin term that means ―In its original place or position‖. Gelation happens through crosslinking of the polymer chain, which can be attained through covalent bond formation (chemical crosslinking) or non-covalent bond formation (physical crosslinking). Methods of forming are the Cold method the and Hot method. Approaches of in-situ gel are physiological stimuli, physical changes in biomaterials, and chemical reactions.

Keywords: In- situ gel, Central Nervous system, Nasal drug delivery system, Intra- nasal, Drug delivery system, Central nervous disorder.