Abstract

EVALUATION OF IN-VIVO GASTRO PROTECTIVE ACTIVITY OF VARIOUS EXTRACT OF VENTILAGO MADERASPATANA BARK INDUCED BY HCl - ETHANOL IN RATS

Velayutham Mani Mala*, P. Pon Malar, P. Essly Selva Jasmine and J. Amutha Iswarya Devi

ABSTRACT

Aim: The Ventilago maderaspatana plant bark is commonly used for the treatment of gastric ulcers. The present study evaluated the gastro protective activities of various solvent extract like chloroform and ethanol of Ventilago maderaspatana bark against ulcer lesions induced by HCl - ethanol in rats Methodology: The shade dried bark part of powder was extracted with chloroform and ethanol by continuous hot percolation method using Soxhlet apparatus. Results: The ulcer score was reduced from group 1 negative control was 7.20 ± 0.72 ulcer indexes and there are no ulcer inhibitions. Then group 2 standard drug of sucralfate was 2.5 ± 0.25** ulcer index and 65.27% of percentage ulcer inhibition. Group 3 chloroform extract (100 mg/kg) was 6.5 ± 0.65* ulcer index and 9.72% of percentage ulcer inhibition. Group 4 chloroform extract (200 mg/kg) was 5.5 ± 0.55* ulcer index and 23.61% of percentage ulcer inhibition. Group 5 ethanolic extract (100 mg/kg) was 4.2 ± 0.42* ulcer index and 41.66% of percentage ulcer inhibition. Group 6 ethanolic extract (200 mg/kg) was 2.9 ± 0.29* ulcer index and 59.72% of percentage ulcer inhibition. Conclusions: The investigation for the gastro protective activity revealed that the ethanolic extract of Ventilago maderaspatana showed a comparable dose dependent gastro protective activity in HCl – ethanol induced method. The chloroform extract of Ventilago maderaspatana was devoid or less active against the gastric lesions induced by this method.

Keywords: Aantiulcer activity, Chloroform, Ethanol, sucralfate and Ventilago maderaspatana