Abstract

SYNTHESIS, CHARACTERIZATION & SCREENING FOR ANTICONVULSANT ACTIVITY OF BENZOTHIAZOLE DERIVATIVES

Amulya Satsangi, Shobhit Srivastava, Sanjay Kumar and Sujeet Kumar Gupta*

ABSTRACT

Background: Anticonvulsants are commonly used to treat seizure disorders but may also be used to treat other medical conditions, including chronic nerve pain and mental health disorders anti-consulvant Drug are clinically used as anti-consulvant, or antiepileptic agents or anti sizzure but they have the drawbacks of causing poor appetite or fatigue. Recently, benzothiazole derivatives have shown significant and less Aplastic anemia activity. The present study deals with the synthesis and pharmacological assessment of a series of novel benzothiazole derivatives bearing 2-aminobenzothiazole scaffolds as anti-sizzure and anti epilyptic agents. Methods: The preparation of the necessary benzothiazole analogues take hold of processes, as shown in Scheme 1. The related condensation reaction is produced in the first steps by the reaction of substituted benzaldehyde and substituted aromatic aniline with glacial acetic acid. (2a-c). In order to produce the desired compound, oxidative ring bases were given time to react using glacial acetic and ammonium thiocyanate. (3a-c).In this investigation Title, synthesize seven new benzothiazole derivatives (6a-g) and evaluated them using the maximal electric shock method (maximum electrical shock method) for its anti-convulsion properties. At the beginning, synthesis 2-Aminobenzothiazole at 05 °C using the shiff base technique and bromination followed by an oxidative ring. benzothiazole derivatives were synthesized and characterized by IR, NMR spectroscopy and elemental analysis. Result: All elemental analysis, IR, 1H NMR values were found to be prominent. A test for anti-consulvant activity demonstrated that (7e) (E)-2-(2,6-dichlorobenzylidene)-1-(4-nitrobenzo[d]thiazol-2-yl)hydrazine, (E)-2-(4-nitrobenzylidene)-1-(4-nitrobenzo[d]thiazol-2- yl)hydrazine(7f),(E)2(4ethoxybenzylidene)1(4chlorobenzo[d]thiazol2yl)hydrazine(7g) exhibited significant anti-consulvant compared to control group. Conclusion: A results of the current research show that substitution at substitution benzothiazole derivative products with benzaldehyde scaffolds have potent anticonsulvant activities.

Keywords: Schiff base reaction, MES model, anticonvulsant activity.