Abstract

CHALCONE: A SIMPLE SCAFFOLD WITH HUGE ANTI-INFLAMMATORY POTENTIALS

Kamini Kashyap*

ABSTRACT

Chalcone or (E)-1,3-diphenyl-2-propene-1-one scaffold has gained considerable scientific interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety of derivatives and exhibiting broad range of promising pharmacological activities by modulating several molecular targets. Several natural and (semi) synthetic chalcones have demonstrated admirable anti-inflammatory activity due to their inhibitory potential against various therapeutic targets like cyclooxygenase (COX), lipooxygenase (LOX), interleukins (IL), prostaglandins (PGs), nitric oxide synthase (NOS), Leukotriene D4 (LTD4), intracellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), TLR4/MD-2, etc. Multi-targets of inflammatory interest, related inflammation reactions, ulcers and their treatment by chalcone-based inhibitors have also been discussed. In this review, a comprehensive study on molecular targets/pathways involved in inflammation, mechanism of actions (MOAs), structure activity relationships (SARs) and patents have been highlighted.

Keywords: Chalcone, Inflammation, Mechanism, Molecular targets, SAR, Inhibitors.