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Abstract

A NEW SPECTROSCOPICAL DETERMINATION AND STABILITY INDICATING ASSAY FOR THE ESTIMATION OF CURCUMIN IN API AND AYURVEDIC FORMULATION HARIDRA CAPSULE

Thejeswari. Y*, Rubesh Kumar. S, Duganath. N, Bharath Rathna Kumar. P, Devanna. N.

Department of Pharmaceutical Analysis, JNTUA - Oil Technological Research Institute, Anantapur -515001, Andhra Pradesh, India.

ABSTRACT

A simple and sensitive spectrophotometric method was developed for the determination of curcumin either in API or in ayurvedic formulations. Curcumin shows the absorption maxima at 418.5 nm. Beer's law is obeyed in the concentration range of 1-6 μg/ml. In present study an assay method was developed for the marketed ayurvedic formulation haridra, the percentage purity was found to be was 100.00% w/v respectively. The proposed method was successfully validated as per the ICH guidelines for API and ayurvedic formulation containing curcumin. The percentage recovery studies were performed and the percentage recovery was found to be 98.01-100.185 %w/v, the system was found to be linear and with a correlation coefficient (r2) of 0.9993, method was found to be precise with relative standard deviation of 0.85, detection limit and quantification limit was found to be 0.03μg/ml, 1μg/ml respectively. The stress degradation studies were performed for the API and marketed formulation as per the ICH guidelines, the degradation was observed in oxidative stress, hydrolytic degradation under alkaline condition, hydrolytic degradation under acidic condition, photolytic degradation and dry heat induced studies.

Keywords: Curcumin, methanol and Stress degradation.


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