Abstract

REVIEW ON CHRONOPHARMACOLOGY IS THE BIOLOGICAL CLOCK

Vishakha Mahadev Divekar*, Prof. Santosh Waghmare and Prof. Hemant Kamble

ABSTRACT

Chronopharmacology is a study of way and duration to that the pharmacokinetic and dynamics of medicine straightly damaged by internal biological rhythm and drug dosing time affect biological timekeeping and biological rhythms. Chronopharmacology builds by pharmacotherapy, pharmacokinetics, and toxicity. Chronopharmacotherapy is considered to science that explicates the biological pulse depended on medicine. The drug effective and toxic vary depending on dosing time involved with twenty-four hours. The circadian clock is under control and maintaining the behavioral and physiological function of the body like physiology and behavioral action managed in “master clock” in the SCN (suprachiasmatic nucleus) of the thalamus, other are managed by “laborer” vibration separate in brain sector or body tissues. In this treatment pharmacokinetics and pharmacodynamics, action maintains in the circadian clock. Chronopharmacological principle currently used in different cardiovascular diseases such as pulmonary embolism, angina, hypertension, etc. in circadian pattern blood pressure change in a day. To regularly monitoring blood pressure in morning and night the reveals a pattern with the lowest amount of systolic and diastolic pressure but midnight to morning 4 am blood pressure values different compare with after morning 7 am tonight. Blood pressure level increases in the early morning and reduces during sleeping time. Suddenly raise in BP are leads to a rise in heart rate. It caused by the synthetic reaction process on the body and expressed into the bloodstream to produce different actions in the body.

Keywords: Chronopharmacotherapy, Angina, Hypertension, Circadian rhythm, Pharmacodynamics, Pharmacokinetics.