Abstract

ETHOSOMES: A NOVEL DEFORMABLE VESICULAR CARRIER FOR TRANSDERMAL AND TOPICAL DELIVERY

Nikita S. Jain*, S. D. Pande, Dipti U. Padole, Roshani A. Sawarkar and Tushar G. Ingle

ABSTRACT

Transdermal drug delivery system networks are generally concerned with poor penetration of therapeutically active compounds. The stratum corneum (SC) is the primary barrier of the skin that prevents drug particle permeation. Skin is a constitutional organ and the body's most easily manageable organ. The objective of the transdermal drug delivery system is to cross the stratum corneum. Out of this, a few progressive approaches containing liposomes, niosomes, ethosomes, and transferosomes are majorly used to boost the permeation of drugs and restorative agents across the SC barrier. Among these vesicles, ethosome emerges as a magnificent substitute for topical drug delivery. Ethosomes are the ultimate pioneering vesicular structure, with a high level of ethanol that ensures better drug penetration into the deeper layers of skin. These carriers are planned for their proficient transport of drugs or therapeutic agents. Even though ethosomal systems are theoretically complex, they are much smoother to assemble, more reliable, and adequate when used together, which has a high impact on their application. This article specifies comprehensive information about the ethosomal structure, the types of ethosomes based on their components, and their means of preparation. Evaluation parameters and their numerous applications to treat miscellaneous afflictions are also reviewed in this article. Ethosomes offer a tremendous number of important benefits, including improving the efficiency of the drug, improving patient consent and comfort, and lowering the total cost of treatment. Ethosomes are ingenious carriers for the transfer of therapeutic agents.

Keywords: Ethosomes, Permeation, Topical, Transdermal, Vesicles.