Abstract

METHODS FOR SCREENING ANTIUROLITHIATIC POTENTIAL

Gifty Ann Alex*, Sumi James, Sherly Eapen and Dr. Santhosh M. Mathews

ABSTRACT

Urolithiasis is a widespread health issue with a high recurrence rate. The complex process of kidney stone formation, also known as urolithiasis, is brought on by a series of physicochemical processes, including supersaturation, nucleation, growth, aggregation, and retention of crystals inside the kidney. Numerous in vitro and in vivo models of urolithiasis have been created by scientists in an effort to mimic human urolithiasis. In vivo models depict the pathological implications of urolithiasis, while in vitro models allow the study of renal stone production. The current review article gives a general overview of the various in vitro and in vivo models for the assessment of urolithiasis.

Keywords: Urolithiasis, Calcium oxalate, Ethylene glycol.