Abstract

A REVIEW ON PSORIASIS PATHOPHYSIOLOGY, CLASSIFICATION, DIAGNOSIS, MECHANISM OF ACTION, RISK FACTORS AND TREATMENT.

Priyanka P. Chirde*, Akshay M. Kasambe and A. S. Jiddewar

ABSTRACT

Psoriasis vulgaris is most common, chronic inflammatory skin disease with a complex etiology involving genetic risk factor and environmental trigger. Patients with psoriasis experience substantial morbidity and increase rates of inflammatory arthritis, cardiometabolis disease and mental health disorder. For patients with mild psoriasis, topical agents remains the mainstay of treatment and includes topical corticosteroids, vitamin D. Analogues. The first line treatment of moderate to severe plaque psoriasis because of their efficacy in treating it and are acceptable at all safety profiles. Some inhibitors are tumor necrosis factor which includes adalimumab, cetrolizumab. Some cytokines inhibitor are cytokine IL – 12, IL – 17. Oral treatment are also available such as methotrexate, cyclosporine. Light therapy is available to treat plaque psoriasis i.e UV – B phototherapy. Psoriasis may also be associated with auto-inflammatory and auto- immuno disease. This review gives information about pathophysiology, mechanism of action and treatment of psoriasis. This review also gives information about several types of classes like plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, erythrodermic psoriasis, psoriatic arthritis, In this review, we also summarize the risk factors which is responsible for onset and exacerbation of psoriasis in order to facilitate prevention.

Keywords: TNF, HBV(hepatitis B virus), TB(tuberculosis), cAMP.