Abstract

SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG BY SOLID DISPERSION TECHNIQUE

Rajesh Ramoliya*, Shabnam Khan, Ramakant Sharma, Jeevan Patel and Dr. Rakesh Patel

ABSTRACT

The objective of proposed research work is to enhance the solubility and dissolution rate of Gliclazide using Polyvinyl Pyrrolidone (PVP K-30) and Hydroxypropyl methylcellulose (HPMC E4. Limited drug absorption resulting in poor bioavaibility is paramount amongst the potential problem that can be encountered when delivering an active agent via oral route. Drug absorption from gastrointestinal (GI) tract can be limited by a variety of factors with most significant contributors being poor aqueous solubility and/or membrane permeability of the drug molecule. When delivering an active agent orally, it must first dissolve in gastric and/or intestinal fluid before it can then permeate the membranes of GI tract to reach systemic circulation. Therefore, a drug with poor aqueous solubility will typically exhibit dissolution rate limited absorption, and a drug with poor membrane permeability will typically exhibit permeation rate limited absorption. hence it is very useful to find appropriate formulation approaches to improve aqueous solubility and thus dissolution of poorly soluble drugs. Gliclazide (GLZ) is the drug of choice for dissolution enhancement using polymers such as Polyvinylpyrrolidone (PVP K-30) and Hydroxypropyl methylcellulose (HPMC). Thus improvement of solubility and dissolution of Gliclazide from its dosage form is an important issue.

Keywords: Solubility Enhancement, Gliclazide, Solid Dispersion Technique.