Abstract

PHARMACOGNOSTICAL AND PHARMACEUTICAL ANALYSIS OF KARVELLAKA EXTRACT TABLET-AN AYURVEDIC HERBAL FORMULATION FOR PRAMEHA-PURVAROOPA (PRE-DIABETES)

Dr. Karan Surati*, Dr. Mandip Goyal, Dr. Harisha C.R. and Dr. Vinay Shukla

ABSTRACT

Background: Karvellaka extract tablet is given as one of the drugs for management of high blood sugar levels, as anti-Hyperglycemic drug. Plant-based medicine has been used cost-effectively worldwide to treat diabetes. In fact, in many parts of the world, especially poor countries, this may be the only form of therapy available to treat diabetic patients So, for initialization of standardization and assurance of quality of herbal compounds pharmacognostical and pharmaceutical analysis should be done. Methods: Karvellaka extract tablet was subjected to microscopic evaluation for pharmacognostical, physiochemical analysis like loss on drying, ash value, pH value, acid insoluble ash, water soluble extract, alcohol soluble extract and high-performance thin layer chromatography (HPTLC). Results: Pharmacognostical study showed the presence of certain identifying characters of the main ingredient of Karvellaka extract tablet which is ripe fruit of bitter gourd only. In pharmaceutical study, preliminary physiochemical analysis showed that ash value of it is 12.92 w/w, loss on drying 6.52 % w/w, water soluble extract 70.84 % w/w, alcohol soluble extract 5.8 % w/w and HPTLC showed 4 spots in 254 nm and 11 spots in 366 nm. Conclusions: Pharmacognostical and physico-chemical observations revealed the specific characters of active constituents of Karvellaka extract tablet and confirmed the purity and genuinity of the drug.

Keywords: Karvellaka extract tablet, Momordica charantia, Prameha-Purvaroopa, pre-diabetes, pharmacognosy, pharmaceutical analysis.