Abstract

DESIGN AND EVALUATION OF PRONIOSOMAL GEL LOADED WITH FLUVOXAMINE MALEATE FOR THE TREATMENT OF DEPRESSION

K. Jyothsna*, Vasudha Bakshi, M. Venkata Swamy, Bolledla Nirosha, K. Pravalika and Samyuktha Metta

ABSTRACT

Proniosomes are a nonionic surfactant-coated dry formulation of water-soluble carrier particles that may be metered out as needed and rehydrated to form niosomal dispersion right before usage after a brief agitation in hot aqueous media. Drugs can be targeted to the reticuloendothelial system via proniosomes, which also have the capacity to target other molecules. Proniosome vesicles are taken up preferentially by the reticulo-endothelial system (RES). Opsonin's, a class of circulating blood components, regulate proniosomes uptake. The proniosome is marked for clearance by these opsonin's. Such medication localization is used to treat animal tumor's that are known to spread to the liver and spleen. This medication localization can also be utilized to treat liver parasite infections. The main aim of the present research work is to increase the bioavailability of Fluvoxamine maleate by proniosomal formulation. Drug carriers like liposomes and niosomes have shown advantages such as being cheap and chemically stable but they are associated with physical stability problems such as fusion, aggregation, sedimentation and leakage on storage. Traditional methods which are used for preparation of liposomes and niosomes are time consuming and also required highly specialized equipment’s. In order to avoid these problems proniosomes might be an attractive alternative of niosomes and liposomes. Proniosomes could be hydrated immediately before use, thus would avoid many of the problems associated with aqueous niosomal dispersions and problems of physical stability. The additional convenience of the transportation, distribution, storage and dosing would make proniosomes a promising industrial product. For calibration curve Maximum wavelength λ max of the Fluvoxamine maleate was found to be 246 nm in 0.1N HCL. Solubility of Fluvoxamine maleate in various solvents was found to be the range from 3.3mg/ml - 30mg/ml. For compatibility test IR peak values ranges of pure drug was compatible with mixture and found to be 569.02 - 3936.84 cm-1. pH values was found to be in the range between 5.3-6.4. Spreadability values was found to be in the range between 4.11- 5.15. Drug content analysis values was found to be in the range between 97.51- 99.81. Entrapment efficiency values was found to be in the range between75.34 - 95.82. In vitro studies were carried out for F1-F16 formulations. As per the above evaluation studies pH, spreadability, drug content, entrapment efficiency, in vitro studies results it was conformed that formulation F6 was found to be best formulation.

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