Abstract

FORMULATION AND EVALUATION OF PULSINCAP DOSAGE FORM CONTAINING ACECLOFENAC

M. V. Jhansi Priya* and Harijana Hunumesh

ABSTRACT

The aim of this study was to explore the feasibility of time specific pulsatile drug delivery system of Aceclofenac to treat high blood pressure. It is used to help heart function after a heart attack. From the results obtained from executed experiments it can be concluded that: The Preformulation studies like pH, solubility and UV-analysis of Aceclofenac were compiling with BP standards. The FTIR Spectra revealed that, there was no interaction between polymer and drug. The solubility studies of empty gelatin capsule bodies, which were cross linked with formaldehyde treatment, revealed that they are intact for 24 hrs, and hence suitable for colon targeting. The polymers like HPMC K200M, and Ethylcellulose can be used as hydrogel plugs to delay the release of Aceclofenac. The result of micromeritic properties showed good flow property of the powder blend indicating uniform distribution of drug within the various batches of capsule with negligible loss during the formulation stage. In conclusion, this system can be considered as one of the promising formulation technique for preparing time specific drug delivery systems and in Chronotherapeutic management of high blood pressure. From the preliminary trials it was concluded that it is possible to formulate the pulsatile drug delivery system by the design of time modified chrono pharmaceutical formulation.

Keywords: Formulation, Evaluation, Pulsincap Dosage Form and Aceclofenac.