FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF LOSARTAN POTASSIUM
N. Naidu* and M. Naga Swapna
ABSTRACT
In the present work efforts have been made to develop fast dissolving
tablets of Losartan potassium using direct compression technique
involving Super Disintegrants like cross povidone, sodium starch
glycolate. The pre compression parameters like angle of repose,
bulkdensity, truedensity, compressibility index are with in the IP limit.
The post compression parameters are acceptable and with in the IP
limit. In-vitro drug release at for all the formulations was found to be
95 to 99%and was satisfactory. The optimized formulation (F6, 10%cross povidone) of drug release was found to be is 99% at 30 min.
Keywords: Fast dissolving tablets, Losartan potassium, In-vitro drug release.
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