Abstract

CO-SOLVENT EVAPORATION METHOD FOR ANTI-HIV DRUG NEVIRAPINE TO ENHANCE SOLUBILITY AND DISSOLUTION RATE

Sirisha Gubbala, A Geethalakshmi*, Reshma Lamsa, L.Sambath

ABSTRACT

The objective of the present study was to enhance the solubility and dissolution rates of Anti-HIVdrug Nevirapine by Co-solvent evaporation technique. Nevirapine is an anti-HIV drug having poor water solubility after oral administration. The co-solvent evaporation method was developed for efficient encapsulation of hydrophobic drug in polymer micelles. Different hydrophilic polymers used are HPMC E5 LV and MCC. Solid dispersions of the Nevirapine were developed by rota evaporation and by physical mixture method. Co-solvent evaporated mixture and the physical mixtures are in solid state, was determined by solubility studies, scanning electron microscopy and Fourier transform infrared spectroscopy. Formulations were developed by using these solid dispersions and various excipients like PVP30, Crosscarmellose sodium, Lactose monohydrate. All the prepared batches show good in-vitro release. Among all F5 showed maximum release up to 98.3.The optimized formulation F5 was compared with marketed product showed bioequivalent.

Keywords: Anti – HIV drug, Nevirapine, HPMC E5 LV, MCC, Solubility, Bioavailability, Rota evaporation, Co-Solvent Evaporation