Abstract

COMPRESSED TABLET LOZENGES FORMULATION AND EVALUATION: A REVIEW

Y. A. Patil*, S. S. Jaiswal, A. A. Sheikh and K. R. Biyani

ABSTRACT

Oral solid dosage form varies and have advantages over other dosage form. Lozenges are one of the widely used solid, unit dosage form of medicament which are meant to be dissolved in mouth or pharynx. Compressed Tablet Lozenges are palatable unit dosage form administrated in the oral cavity, which is the most common route and easiest way of administering a drug and have a bright future as novel method of delivering drugs for local and systemic effect. However, paediatric, geriatric patients show less compliance in swallowing tablets and capsules due to difficulties in swallowing and bitter taste of many drugs when formulated as liquid dosage form. The benefit of the Compressed Tablet Lozenges is they increase the retention time of the dosage form in the oral cavity which increases bioavailability and reduces first pass metabolism. The medicaments which can be formulated as lozenges include local anesthetics, antihistamines, antitussives, antiseptics, decongestants, demulcents and antibiotics. Lozenges are evaluated by hardness, friability, diameter and thickness, weight variation, moisture content, drug content/ assay, etc. Drug – Excipients interaction are studied by FTIR. In- vivo study, In vitro study. Compressed Tablet Lozenges provide easy administration, convenience to patient, patient compliance, and efficient treatment of low drug dosing, immediate onset of action, reduced dosage regimen, and cost effectiveness.

Keywords: Compressed Tablet Lozenges, Troches, Medicaments, Excipients.