Abstract

FORMULATE AND EVALUATION LAMIVUDINE FLOATING MICROSPHERES BY USING GELATIN FOR SUSTAINED DRUG RELEASE PATTERN

Vothani Sarath Babu*, Uday Kiran Eeduru, K Sandhya Rani, Anama Deepa, Ch. Apparao

ABSTRACT

The objective of the study was to develop oral controlled release drug delivery system of lamivudine Floating Hollow Microspheres of Lamivudine was formulated by Emulsion Polymerization method. From the evolution of lamivudine microsphere the particle size shows least particle size of 1027 ± 8.6 μm with optimum polydispersity index of about 0.511, which infer that the F2 microspheres has been uniformly dispersed in phase and it shows a good Dispersibility. SEM study showed that the Microspheres prepared by using polymer predominantly shows spherical in shape with smooth surface. F2 possess expected desired cumulative sustained release pattern (i.e., 88.63% in 24th hour). Further Release Kinetics revealed that the drug release for formulation F2 follows Zero order kinetics (r2=0.9900), with release exponent value of n = 0.860 (peppas), indicating Non-Fiskian Diffusion type release. This kind of release is the characteristics of swelling-controlled system in which the rate of solvent uptake into a polymer is largely determined by the rate of swelling and relaxation of the polymer chains.

Keywords: Hallow Microspheres, Lamivudine, Gelatin.