Abstract

REPURPOSING ANTI-INFLAMMATORY DRUGS FOR THE MANAGEMENT OF COVID-19

Shubhada Khade*, Santosh Chavan, Avinash Nimbalkar and Vaibhav Gawade

ABSTRACT

SARS-CoV-2 is contagious in humans and has spread quickly over the world. Survival and death after coronavirus infection range from 6 to 41 days. Common signs of infection include fatigue, muscle discomfort, sore throats, dry coughs, high fevers, and respiratory issues. A coronavirus strain may have made SARS more easily transmitted. No particular medication or vaccine has been shown to be especially effective. Prevention can be taken by wearing masks, practicing good hand hygiene, avoiding contact with the public, identifying cases, tracing contacts, and establishing quarantines. 205 nations had recorded cases of Covid-19, the virus-caused sickness. The crucial duty of effective risk communication falls on the media. The coronavirus genome contains several non-structural proteins (NSP) in relation to the four structural proteins nucleocapsid (N), membrane (M), spike (S), and envelope (E). Nsp2 influences the host cell's survival signaling pathway; Nsp4 modifies ER membranes and has transmembrane domain 2 (TM2); Nsp5 takes part in the replication-related polyprotein process. NSAIDs are some of the most widely used medications and have a variety of applications. NSAIDS have reportedly been linked to a higher incidence of side effects when administered to individuals with acute infectious respiratory infections, particularly COVID-19. In the midst of a pandemic with a high mortality rate, the collapse of health systems, and devastating effects on the economy, a fast solution is crucial. In this review, we described anti-inflammatory drugs as used as a realistic alternative in the treatment of COVID-19.

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