Abstract

EVALUATION OF BIOCHEMICAL IN HIV-INFECTED SUBJECTS PRE AND AFTER LONG-TERM COMMENCEMENT OF HAART IN FEDERAL TEACHING HOSPITAL GOMBE

Abubakar Sani Ibeh* and Nancy

ABSTRACT

Purpose: The aim of this study is to evaluate the effect of Long-term HAART On Biochemical, before and after Long-term HAART therapy at federal teaching hospital Gombe. The Human Immunodeficiency Virus (HIV) infection causes the acquired immunodeficiency syndrome (AIDS), which is a systemic disorder characterized by severe impairment and progressive damage of both cellular and humoral immune responses. Liver disease is known to be caused by a number of antiretrovirals. Following exposure to the drug, the toxic moiety induces some type of stress or functional disturbance, with mitochondrial injury being one of the most important targets recognized.[2] Methods: A Cross sectional study was conducted from May to December 2021 on 132 HIV infected adults before Commencement of HAART and after treatment for more than six months in the study hospital. 66 were HIV subjects’ antiretroviral therapy Naive while another Sixty - Six (66) of the subjects were HIV Sero-negative clients, whose age were greater than or equal to 15 years were enrolled in the study and had a mean ± SD age of as 30.533I ± 1.239 and 29.067 ± 0.741 years. Data was collected by using structured questionnaire that included variables related to socio-demographic characteristics and clinical conditions of the study individuals. A volume of 4mls of venous blood was taken from forearm antecubital vein with appropriate aseptic technique. Measurements of Biochemicals were made Before and after commencement of HAART using Selectra PRO S. analyzer respectively. P<0.05 was considered as significant. Results: The result of the analysis indicated that the mean±se of Glucose (mmol/L), Creatinine (mg/dL), AST and ALT parameter of platelets for the control group are 5.58 ± 0.16, 85.02 ± 1.52, 21.30 ± 1.75, and 24.23 ± 1.66 respectively. The mean±se of the treatment naïve for Glucose (mmol/L), Creatinine (mg/dL), AST and ALT are 72.12 ± 3.19, 6.65 ± 0.81, 27.08 ± 1.49, and 29.92 ± 1.65 respectively. Also, the mean±se of the treatment/HAART for Glucose (mmol/L), Creatinine (mg/dL), AST (U/L) and ALT (U/L) are 5.42 ± 0.20, 84.55 ± 2.43, 27.62 ± 1.68, and 32.98 ± 1.42 respectively after six months of HAART compared with the baseline. Conclusion: It is evidence from this study that unlikely that a subjects on long-term HAART treatment will develop severe liver toxicity if treatment is started before any organ damage occurs.

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