Abstract

REVIEW ON: FORMULATION AND EVALUATION OF HARD GELATIN CAPSULE OF LOSARTAN POTASSIUM

Dipali Mohan Shende*, Vaishnavi Kalamb, Pooja D. Dadmal and Rupali H. Chavhan

ABSTRACT

The formulation of the hard gelatin capsule used in this trial, which contains granules of the hypertension medication Losartan potassium, was created to ensure quick drug release from the dosage form, to promote therapeutic efficacy, and to improve patient compliance. Hard gelatin capsule benefits include the potential for quick medication release, versatility in formulation, and sealed hard gelatin capsules' effective resistance to atmospheric oxygen. This work's main objective is to develop immediate medication release action from a hard gelatin capsule containing potassium losartan granules. Wet granulation was used to create the formulations, which were then placed into empty hard gelatin capsules for the dissolving trials. The % yield, angle of repose, bulk density, tapped density, Hausner's ratio, and Carr's index of the prepared granules were all measured and assessed. Losartan potassium granules contained in a hard gelatin capsule were also tested for drug content, in-vitro drug release, and disintegration time. According to a stability analysis, the formulation's disintegration time, drug content, and in-vitro drug release did not alter significantly. As a result, formulation was thought to be optimised for immediate.

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