Abstract

THE USE OF HYPROMELLOSE IN NOVEL DRUG DELIVERY SYSTEM (TABLETS)

Subhajit Roy*, Anwesha Adak, Mayukh Jama, Amlan Bishal

ABSTRACT

Hypromellose, Formally known as hydroxypropylmethylcellulose (HPMC), is far the most commonly employed cellulose ether used in the fabrication of hydrophilic matrices. In order to highlight the fundamental factors that influence hypromellose's performance, this review offers a contemporary perspective on the substance and its applicability to hydrophilic matrices. The chemical, thermal, and mechanical properties of hypromellose, hydration of polymer matrices, the mechanism of drug release, and the impact of tablet geometry on drug-release rate are among the subjects covered. Also included are the effects of dissolution media, the incorporation of drug-release modifiers in hypromellose matrices, and the impact of the pH of the gel matrix's internal milieu on the polymer's characteristics.

Keywords: Hypromellose, NDDs.