Abstract

DESIGN AND DEVELOPMENT OF BILAYER FLOATING TABLET OF LISINOPRIL USING DIRECT COMPRESSION TECHNIQUE

Akshay M. Kasambe*, A. S. Jiddewar and Priyanka P. Chirde

ABSTRACT

Lisinopril is an antihypertensive drug with 12hr of half life. Narrow absorption. The development of innovative combination therapy is highly desired to deliver lisinopril to prepare bilayer tablet that can perform quick oral release controlled system. The purpose of this study was to introduce the technology for development of rate controlled oral drug delivery systems to overcome various problems. Tablet were fabricated by direct compression using HPMC and sodium carboxy methyl cellulose polymer. The total floating time, swelling ability and in invitro release studies were carried out in 0.1N Hcl (PH 1.2) at 37± 20c. Statistical data analysis revealed that the optimised formulation containing HPMC and sodium carboxy methyl cellulose had acceptable hardness. Optimum floating behaviors and due to control release pattern. The designe succeeded with developed floating ability and controlled released behavior that increases solubility and availability at the site of absorption. Stability studies of optimized bilayer tablets were carried out according to ICH changes in physical characteristics drug content and dissolution. The results obtained were found to be within limits.

Keywords: floating tablet, HPMC, Dissolution, Ethyl cellulose, polymer, lisinopril, sodium carboxy methyl cellulose.