Abstract

CHARACTERIZATION OF THE DESIGN SYNTHESIS FOR OXADIAZOLE HETEROCYCLIC DERIVATIVES AS ANTITUBERCULAR AGENTS

Laxmikant, Kuldeep Singh*, Shivendra Kumar, Sunam Saha, Anurag, Karan Kumar, Shubham Tomar, Soumyadip Mukherjee, Krishanveer Singh, Urvashi Soni, Yogita Dhurandhar, Sachin Pratap Singh, Surya Prakash and Vivek Kumar Saini

ABSTRACT

Every year, Macrobacterium tuberculosis causes millions of deaths due to highly communicable infections. L, D transpeptidase-2 is required for Mycobacterium tuberculosis cell division union. The molecule oxadiazole has high prospects of inhibiting the Mycobacterium tuberculosis derivative of oxadiazole was synthesized, designed by CADD, and characterized by IR, H1-NMR, and docking using Argus Lab 4.0 software. The newly synthesized compounds were characterized by elemental and spectral methods. Compounds SA, NA, and VS1 are novel compounds. SA, NA, and VS1 show good activity. If the structure of the synthesized compounds is changed, even more, it could change how promising molecules against Mycobacterium tuberculosis could be made.

Keywords: Anti-tuberculosis, oxadiazole, 4, chlorobenzoic acid, docking, L, D transpeptidase-2.