Abstract

DEVELOPMENT AND CHARACTERIZATION OF TOPICAL HYDROGEL CONTAINING ANTIFUNGAL DRUG

Mukesh Kumar Shukla*, Harshit Srivastava and Razia Bano

ABSTRACT

An antifungal medication called griseofulvin is used to treat fungus infections. Griseofulvin undergoes hepatic first-pass metabolism and has a long list of possible adverse effects, hence oral usage is not advised. The purpose of this study was to develop and test a topical hydrogel formulation of griseofulvin for the treatment of cutaneous fungal infections. Several hydrophilic polymers, including carbopol 940 and guar gum, were used to develop topical hydrogel formulations of griseofulvin. Viscosity, spreadability, pH, assay, and in vitro drug release all underwent evaluation testing. An in vitro diffusion test in a Franz diffusion cell employed a cellophane membrane. The physicochemical properties of the formulations did not significantly change after exposure to accelerated temperature conditions (40 2oC). A gel formulation containing 1% w/v Guar gum and 1% w/v Carbopol 940 in a 1:1 ratio was shown to be suitable for topical administration based on an in vitro test. These results demonstrate the Griseofulvin topical gel formulation's viability.

Keywords: Griseofulvin, Franz diffusion cell, Carbopol 940, Guar gum.